Seattle, Wa (PRWEB) April 17, 2014
The 4 Cycle Solution PDF is developed by Shaun Hadsall, who promises to help people lose belly fat within a short period of time. This program contains 4 parts, including:
(PRWEB) April 05, 2014
Acai Berry is a very powerful antioxidant that can help increase energy, boost metabolism, and initiate fat oxidation, while reducing ones total body mass. And now, a persons strong commitment to lose weight is made even easier with the recently opened Weight Loss Management Club, a club sponsored by the experts behind Acai Berry Select themselves.
Click Here to Visit Official Website of Acai Berry Select
This club is open to all men and women who will purchase at least a bottle of the full 30-day Acai Berry supply to initiate weight loss. The club will complement ones efforts in attaining the sexy body that everybody wanted by providing members with an easy-to-follow and very effective online fitness program. The program is specific to an individuals need, as their full physical data is required upon registration. With the information that the user provides, the system is able to come up with a fitness program that would work best for them, and the kind of Acai Berry weight supplement that they take.
The club is exclusive only to Acai Berry Select users, which means any help or information obtained from the database are not made available to the public. First-time and subsequent buyers are automatically enlisted into the program. Immediately, they get full access to all the resources available, every single one of which are guaranteed to provide the best results right from the start.
Click Here to Visit Official Website of Acai Berry Select
What the membership club offers is a series of sensible diet plan suggestions and exercise routines that could ultimately help in reducing weight. Other interesting weight loss tips and tricks are included in the program as well, like the proper drinking habits, correct workout schedule, and a whole lot more. A highly detailed explanation of how Acai Berry Select works is also available. By discovering all the important ingredients of this supplement, individuals will be able to maximize their weight loss activities. With the plethora of information and health resources included with every Acai Berry Select purchase, customers are further assured that a slimmer and sexier body will be theirs in no time.
For more information about Acai Berry Select, check out its official website at http://goo.gl/hceNaC
DeLand, FL (PRWEB) April 15, 2014
*To see if you qualify for this Diabetes Clinical Trial in DeLand, visit Avail Clinical Research on the web (http://www.availclinical.com) or contact us directly at (386) 785-2404. There is no cost to participate, no insurance required, and you may receive compensation for time and travel.
The present study will assess the effect of a new form of therapy on glycemic and lipidemic parameters when incorporated into an existing diabetes treatment with a sodium-glucose co-transporter 2 (SGLT2) inhibitor. SGLT2 inhibition induces negative energy balance by promoting urinary glucose excretion resulting in glucose lowering and weight loss. Stimulation of FaOX under conditions of negative energy balance is hypothesized to be more efficacious than under positive energy balance. Under negative energy balance, it is anticipated that a larger fraction of the acetyl-CoA derived from pharmacological stimulation of -oxidation will enter into the tri-carbocylic acid cycle for complete oxidation rather than accumulating as partially oxidized intermediates, which have been hypothesized to be potentially detrimental. In order to assess the efficacy of this new form of diabetes therapy under negative energy balance, the impact of the agent will be assessed in combination with the combined inhibitor.
Over 6 weeks of combined therapy administration, early signs of efficacy are anticipated to be observed in weighted mean daily glucose (WMDG, the primary endpoint); fasting plasma glucose (FPG) and early changes in HbA1c will serve as secondary endpoints. The data of this study in combination with other Phase 2 clinical studies that may be conducted with this compound, will be used to determine if further investigation of this compound for the treatment of type 2 diabetes (T2DM) is warranted.
BACKGROUND & RATIONALE
Diabetes mellitus is common in the US and worldwide with approximately 90 to 95% of diabetic patients having T2DM and was once mainly seen in adults over the age of 40 years, but there has been a dramatic rise in its prevalence rates, and it is now increasingly diagnosed in younger people in parallel to rising obesity rates. T2DM is characterized by insulin resistance in muscle and liver, a disorder in which cells do not respond effectively to insulin, resulting in higher blood glucose levels. Elevated blood glucose levels signal the need for more insulin over time and with increasing severity of insulin resistance, hyperinsulinemia eventually leads to insulin deficiency as a result of progressive -cell failure in the pancreas.
Approximately 85% of patients with T2DM are obese or overweight, a key factors underlying the development and maintenance of insulin resistance. Individuals with T2DM have an increased risk of developing both microvascular (nephropathy, neuropathy, retinopathy) and macrovascular complications, and are 2 to 4 times more likely to die from cardiovascular disease than adults who do not have diabetes. Several studies have found that by improving glycemic control with pharmacological intervention, the risk of microvascular complications can be significantly reduced. Although these therapies, either singly or in combination, may provide effective glycemic control for some patients, many do not achieve the American Diabetes Association (ADA) target HbA1c (glycosylated hemoglobin) level and glucose control tends to deteriorate over time. Therefore, there is a clear need for new and better therapeutic options that provide effective treatment of T2DM, including therapies that have
the potential to increase insulin sensitivity.
To evaluate the effect on glycemic control (mean glucose) with 200 mg of the new new diabetes drug administered twice-daily over a 6 week study period in adult subjects with T2DM on canagliflozin background therapy.
Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the study:
Evidence of a personally signed and dated informed consent document indicating that the subject (or a legal representative) has been informed of all pertinent aspects of the study.
Subjects who have been diagnosed with T2DM by a medical professional according to the ADA guidelines and are treated with metformin monotherapy at stable doses (greater than or equal to 1000 mg) over the past 3 months and are willing to be switched from treatment with metformin to canagliflozin as background therapy.
While in the study, subjects may continue taking medications prescribed for the treatment of other chronic conditions often associated with diabetes.
Male or female subjects between the ages of 18 and 65 years, both inclusive, at screening.
= Male subjects of childbearing potential must agree to use a highly effective method of contraception throughout the study and for at least 28 days after the last dose of assigned treatment. A male subject is of childbearing potential if, in the opinion of the investigator, he is biologically capable of having children and is sexually active.
= Female subjects must be of non-childbearing potential (NCBP) and must meet at least one of the following criteria:
Achieved postmenopausal status, defined as: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause; and have a serum follicle stimulating hormone (FSH) level within the laboratorys reference range for postmenopausal females;
Have undergone a documented hysterectomy and/or bilateral oophorectomy. Alternatively this may be confirmed by ultrasound;
Have medically confirmed ovarian failure
All other female subjects (including females with tubal ligations and females that do NOT have a documented hysterectomy, bilateral oophorectomy and/or ovarian failure) will be considered to be of childbearing potential.
Body Mass Index (BMI): 25 kg/m2 and a total body weight >50 kg (110 lbs).
HbA1c at screening (with one repeat if necessary): 7.0 and 10.0%.
C-peptide >1.0 ng/mL in fasting state at screening.
Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
Avail Clinical Research conducts a variety of Clinical Research Studies in Florida. For more information about participating in a Diabetes Clinical Trial, please visit our website or contact us directly at (386) 785-2404.
Discovery of tampered vials leads to Roche cancer drug recall
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Islet Sciences Announces Positive 12-Week Phase 2 Clinical Results for SGLT2 …
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If you are young, one of the more thrilling issues to look forward to is the evening you get your driver license. Their heads are thinking about the locations they will go and pals they will see, but as a parent, your head is likely thinking about the dangers and expense of having a teenaged driver.
Unfortunately, teens are statistically the most likely age group to get into an accident. Because of this, insurance companies bill teenaged motorists the most when it comes to car insurance. Insurance firms need to make money just like any other business and when a motorist makes a claim, they lose money. Therefore they need to charge high-risk motorists more for insurance to cover the higher likelihood that they will be paying claims.
Discount Automobile Insurance for Teenagers
Even though car insurance for teens is high-priced and your young child getting the wheel might be anxiety provoking, fortunately it gets better over time. Info from Examine-Insurers.com
Though a teen-aged motorist will surely include an additional expense to your monthly funds, and their insurance will likely constantly be greater than an grown-ups, there are still a few things which you are able to do to create down these prices. So proceed through this list supplied as a cortesy from our partner http://compare-insurers.com
- Variety of auto – buying a reasonable, trustworthy, secure vehicle to your adolescent can save you cash. Avoid sports cars and other cars that are more likely to be involved in an injury, stolen, or vandalized. When you can, update the auto with the latest safety and security features.
- Comparison shop – store online and locate as numerous car insurance quotes as possible. This provides you the best opportunity at finding a good deal and optimizing your price reductions.
- Reductions – there are a myriad of reductions accessible for teen-aged motorists including good pupil, low-mileage, driver’s education course discount, being apart at college with no car, multi-auto, and multi-coverage discounts among the others.
When you are youthful, perhaps one of the most thrilling things to look ahead to is the evening you get your driver license. Many adolescents look forward to possessing their first auto and having more independence than they did in the past. Their heads are thinking about the locations they’ll go and pals they will see, but as a parent, your head is likely thinking about the dangers and expense of having a teenaged driver.
Sadly, teens are statistically the most likely age-group to get involved with an accident. This is only because they have less expertise on the road, less caprice control, more of a feeling that it “can’t occur to them’, more distractions, and they sometimes do not make the best decisions. Due to this, insurance providers bill teenaged drivers the most when it comes to automobile insurance. Insurance agencies need to make money just like any other company and when a motorist makes a claim, they lose money. So they need to bill risky motorists more for insurance to cover the higher likelihood that they will be paying claims.
Discount Vehicle Insurance for Adolescents
Even though car insurance for adolescents is pricey and your young kid getting the wheel might be anxiety provoking, fortunately it gets better over time. As time passes and expertise your teenager will hopefully become a confident, safe driver, and his or her insurance rates will eventually come down to reflect this. For the time being, doing everything you can to lower their insurance premium will save you and your teen money each month and make their summer job dollars stretch further. Information from Evaluate-Insurers.com
Even though a teen aged driver may definitely include another cost to your monthly budget, and their policy contract will likely always be higher than an adults, there are still some things you can do to create down these prices. So proceed through this list supplied as a cortesy from our partner http://compare-insurers.com
- Sort of car – buying a sensible, trustworthy, safe automobile to your teenager could help you save cash. Avoid sportscars and other automobiles that are more likely to be involved in an injury, stolen, or vandalized. If you can, upgrade the auto with the latest safety and security attributes.
- comparison-shop – shop on line and locate as many car insurance estimates as possible. This gives you the finest opportunity at finding a good deal and maximizing your reductions.
- Discounts – there are an array of reductions available for teen-aged motorists like good student, low mileage, driver’s education course discount, being apart at school with no auto, multicar, and multiple-policy reductions among others.
Princeton, N.J. (PRWEB) April 11, 2014
Fighting the nations related epidemics of obesity and type 2 diabetes mellitus will take a nationwide strategy that increasingly tailors treatment to individual patient needs, and new approaches are need to get patients to take medications and make lifestyle changes to be healthier.
That was the consensus of an expert panel convened Thursday by The American Journal of Managed Care to open its two-day conference, Patient-Centered Diabetes Care: Putting Theory into Practice, which is taking place at the Princeton Marriott at Forrestal. The conference continues today, opening with a keynote address by Robert A. Gabbay, MD, chief medical officer at the Joslin Diabetes Center, Harvard Medical School.
Panelists taking part were Jeffrey D. Dunn, PharmD, MBA, senior vice president, VRx Pharmacy Services, LLC, Salt Lake City, Utah; Yehuda Handelsman, MD, FACP, FACE, FNLA, medical director and principal investigator, Metabolic Institute of America, Tarzana, Calif., and president-elect of the American Association of Clinical Endocrinologists (AACE); Maria Lopes, MD, MS, chief medical officer, AMC Health, New York City; and Kari Uusinarkaus, MD, FAAFP, FNLA, associate medical director, adult primary care and health management, Colorado Springs Health Partners, Woodland Park, Colo.
Peter Salgo, MD, professor of medicine and anesthesiology at Columbia University and associate director of surgical intensive care, New York-Presbyterian Hospital, served as moderator. The 90-minute discussion covered the challenges to treatment, including woeful adherence rates to therapies despite recent advances in medication; how to weigh medical therapy against surgical options; and when the newest classes of diabetes therapies, the DPP-4s inhibitors, GLP-1 receptor agonists, and SGLT2 inhibitors are indicated. The webcast will be shown on http://www.ajmc.com in upcoming weeks.
The discussion opened with a snapshot of obesity and diabetes in the United States, where the latest figures reported by the American Diabetes Association (ADA) show nearly 26 million people are affected by diabetes, almost all off it type 2. Increases in diabetes have tracked rising rates of obesity geographically in recent decades, a point Dr. Handelsman noted when he said that California is where Mississippi was, years ago.
Dr. Handelsman said that turning the tide, on diabetes would require a nationwide, proactive intervention, with government health agencies taking a role. The trends are not good, the panelists agreed. Dr. Uusinarkaus said though his home state of Colorado is statistically the nations fittest, Our obesity has finally crept up. The trends are certainly in the wrong direction.
The statistics outlined by Dr. Salgo are alarming: He quoted an ADA study that shows the economic costs of diabetes are $ 245 billion a year in the United States, including $ 176 billion in direct medical cost (28 percent is for medication).
When asked by Dr. Salgo if therapies alone could do the trick, given the woeful statistics on lifestyle modification, Dr. Handelsman insisted that past failure could not be a reason to give up things like better diet and exercise. We know changing lifestyle works, he said.
The challenge comes when its time to pay for intensive, personalized efforts to help patients exercise and make better food choices over the long haul. These interventions are expensive, and not all insurers or employers are willing to include these items in a health plan.
Dr. Lopes agreed that prevention has to be part of the solution if the nation is to bend the cost curve on treating diabetes and its many complications. Tailoring treatment to individual patients is essential, she said.
We have to figure out what works, and more importantly, what does not work. A lot of this is going to be predicated on data from real-world situations, Dr. Lopes said. The panelists agreed that methods such as using newsletters or mailed reminders to diabetes were outdated and simply did not work. Group counseling has produced better results, Dr. Lopes said.
New therapies that help patients lose weight alongside controlling diabetes offer promise, for the patient can see the progress; studies show that glycated hemoglobin (A1C) levels drop along with weight loss, even when the amount lost is initially small. Dr. Uusinarkaus said the promise of significant weight loss can help motivate a patient who might refuse an injectable drug for diabetes to give it a try.
Dr. Dunn said payers and pharmacy benefit managers are open to new approaches and are not unwilling to pay for relatively expensive new therapies if they see signs of progress. Payers and employers balk, he said, when a patient is taking up to four drugs and still not achieving control of A1C or blood pressure.
Every plan out there has thrown everything under the sun at diabetes, Dr. Dunn said. Plans cannot afford to provide intensive monitoring of every person with diabetes, but it does make financial sense to identify those patients most at risk of hospitalization or serious complications, and aim highly targeted efforts at guiding them to better health. We need risk stratification and coordination, he said. It has to be done on the right patients.
Dr. Dunn also called for shared risk among providers, payers, and the pharmaceutical companies that develop new, expensive treatments. Right now, he said, the risk is all on the payer, and that cannot continue.
About the Journal
The American Journal of Managed Care, now in its 20th year of publication, is the leading peer-reviewed journal dedicated to issues in managed care. In December 2013, AJMC launched The American Journal of Accountable Care, which publishes research and commentary devoted to understanding changes to the healthcare system due to the 2010 Affordable Care Act.
FOR INFORMATION CONTACT:
Mary Caffrey mcaffrey(at)ajmc(dot)com
(609) 731-8802 (Friday only)
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Rock Hill, SC (PRWEB) April 08, 2014
There are many advertised ways to lose weight, some require special pills or foods. One doesnt need a diet, they need a lifestyle change, says Dr. Grewal, creator of the SlimPlate System, weight loss using real food. We as physicians need to show society how to lose weight effectively.
Dr. Grewal and Dr. Nwe give their advice on how to save money on healthy foods:
1. Choose a diet that lets you eat real food – Spending extra cash on certain foods can hurt ones wallet, also special trips to different stores shouldnt be necessary. One should be able to eat real food and form better eating habits while eating the same food as their family.
2. Choose a diet which sustains the weight loss – Choose a method that allows you to lose the weight so you dont have to diet again and again. Yo-yo dieting can be a danger to someone’s health and costs money. That is why the doctors designed SlimPlate System for weight loss using real food and made it a one-time purchase so there is no recurring cost involved.
3. Choose a safe diet plan – Extreme diet plans like very low calorie diets can cause health problems and you may end up spending more for your health.
4. Dont believe in gimmicky diet pills – Dont waste money on gimmicky pills touted as weight-loss vitamins. If it was that easy, they wouldnt have to sell it. If a diet doesnt require a lifestyle change, then it will not provide long-term weight-loss results.
5. When a friend recommends a diet, check the long-term results on the diet before considering it – Did users gain the weight back? Diets are different for each individual; it is best to choose a natural weight loss that offers long-term results. Look and see; did people on that diet really kept the weight off or they gained it even more?
The SlimPlate System, created by the doctors, is unique as it saves money by not having to buy frozen foods or diet pills. People can lose weight and build a diet around the everyday foods they eat by using the SlimPlate System. More information about SlimPlate System weight loss method can be obtained at http://www.slimplatesystem.com.
Credentials: Dr. Sandeep Grewal and Dr. Myo Nwe are the founders of Ace Medical Weight Loss Center, the inventors of the SlimPlate System and its related mobile apps. Dr. Nwe is a diplomate of the American Board of Obesity Medicine and Internal Medicine. Dr. Grewal a diplomate of the American Board of International Medicine. He has been named one of Charlotte Business Journals Forty Under 40, received the magazines 2012 Innovation in Healthcare award and Vitals Top 10 Doctor 2013 award.
Interviewing Availability: North and South Carolina, nationwide by arrangement and via telephone; often available last-minute.
Contact: Dr. Sandeep Grewal, (803) 325 2236 (SC); doctor(at)acemedicalgroup(dot)org
Related Diet Pills Press Releases
Houston, TX (PRWEB) April 04, 2014
Unleash Your Thin is an eating plan that promises to help people lose weight in a sustained manner. This has caught the attention of HealthyandFitZone.coms Stan Stevenson, prompting an investigative review.
Our Unleash Your Thin review shows that it is about altering your eating habits for good, and changing the way you think about food. This program is designed to help you lose weight, and then keep it off for good. This is one of its most important aspects, reports Stevenson. The diet is designed to help you gradually change your eating habits to healthier ones, and its this very fact that will see you changing your diet for good while staying at a weight thats healthy for you naturally.
To learn more or get access to the program click here.
Unleash Your Thin is provided in four different sections: The Fat Burning Blueprint, The Craver Crusher Action Guide, The 10-Minute Meal Guide, and Membership to the Private Forum. The Fat Burning Blueprint is a 130-page complete diet guide that tells people everything they need to know about which foods they should be eating, and even more importantly, which ones to avoid. The 10-Minute Meal Guide is a handy day-to-day guide that covers meals, shopping lists, and recipe guides. The Craver Crusher Action Guide addresses of cravings, so that they diminish and eventually go away.
By discovering the foods that work best for your body and gaining all the knowledge you need is provided throughout the program, you will realize that once you re-program your body to use nutrition in the correct manner, youll probably never crave those forbidden foods again, says Stevenson. The program targets other important issues such as foods that cause sluggishness, depression, and those that increase fat storage. It is designed not just to help you lose weight.
Unleash Your Thin is so much more than just a diet; its a way of changing your eating habits and dress size forever. This program is designed for anyone who needs to lose weight. You will never have to worry about not being able to eat your favorite food again. It not only will help you lose weight, but also reduce lethargy, promote a better frame of mind, and give you healthy looking skin and hair. When you kick start your new eating plan, you begin to see results fast.
Those wishing to purchase Unleash Your Thin, or for more information, click here.
To access a comprehensive Unleash Your Thin review, visit http://healthyandfitzone.com/unleash-your-thin-review.